An worn area of skin on the gentalia. There are several possible causes. The most frequently seen cause of genital ulcers is a sexually transmitted infection, specifically genital herpes or syphilis. Granuloma inguinale and chancroid are tropical bacterial infections that lead to genital ulcers. Lymphogranulama vemereum is a chlamydial infection that creates genital blisters. Betchet’s syndrome is an uncommon condition that leads to tender, recurring ulcers in the mouth and on the genitals. Cancer of the vulva or penis may first arise as a painless ulcer with raised edges.